分子科学公共实验平台
西湖大学分子科学公共实验平台在学校的大力支持下,依托理学院逐步建设以磁共振波谱、色质谱、光谱、X射线谱以及自动化制备筛选等为技术核心的原位、高分辨、高通量分子科学表征体系,在原子和分子系统层面探索化学变化和能量流动的根本原理,服务分子合成、绿色催化、能源材料、环境生态、化学生物、生物物理、药物科学等学科方向,为西湖大学“理工生医”四大学院的蓬勃发展、PI实验室的前沿创新、学生科研素养及数据解析技能的不断提高而全力服务。
平台秉承“技术驱动创新”的理念,以新工具促进新科学的发展,为校内外用户提供最新一代原子/分子谱学表征的7*24小时自主、开放仪器使用环境,现已建立(I)高场原位液体核磁共振、超分辨固体核磁共振、液氦低温脉冲式电子顺磁共振;(II)高分辨高灵敏液质/气质联用、飞行时间二次离子质谱、全元素精准定量、光谱质谱波谱联用;(III)飞秒-秒多时间尺度时间分辨光谱、超分辨荧光/拉曼/紫外/红外光谱成像、原位X射线吸收/发射光谱、近常压X射线光电子能谱、液态金属靶X射线单晶衍射仪及小角散射;(IV)催化化学及化学生物学高通量反应优化筛选系统等一批国际先进水平设备,为新分子、新材料和新工艺的源头创新提供特色、高效的技术支撑与服务。
平台主要由五个专业实验室组成:
(1)磁共振实验室旨在为分子结构、分子间相互作用和分子动力学信息的获取和解析提供新方法技术支撑,通过新型脉冲序列设计,对核磁共振和电子顺磁共振中核自旋和超精细相互作用实现精确操控,使其成为功能分子、生物材料、能源催化、药物分析和生物物理等研究领域的原子级分辨表征工具。
(2)色质谱及化学反应优化实验室面向化学、环境、材料等领域,以小分子、聚合物为研究对象,依靠高灵敏度、高分辨率的各类色质谱技术进行化合物纯化、制备及定性、定量分析,并开展对于新合成分子,尤其是手性异构体分子的色质谱方法研究。
(3)光谱实验室提供从X射线、近紫外、可见光到中红外区的稳态和瞬态光谱的先进原位表征和微区表征,用于能级结构、配位环境、成分价态、分子几何以及化学键性质的研究,实现从皮秒到秒的分子反应动力学监测。
(4)微结构与形貌表征实验室聚焦于发展高分辨、原位与微区XRD分析技术,构建光、电、力、热、磁等多物理场耦合的原位测试平台,通过动态追踪技术突破,实现从静态结构解析到相变过程实时观测的跨越。
(5)高通量精准化学实验室通过高通量实验与高通量筛选双系统,实现高通量自动化的分子合成与功能筛选,应用于催化化学、化学生物学、材料创制、新药筛选等领域,支持从纳升级操作到分子、细胞、类器官水平的全链条科研突破。
各专业实验室均配有在国内外科研单位积累丰富经验的资深技术人员,为仪器维护、人员培训保驾护航,为设备研制、功能开发锐意创新;并瞄准分子科学领域关键的表征技术难题,开展基础性、前瞻性、多学科多技术交叉的分析测试新方法、新工具的研发。与此同时,平台面向社会开放共享,技术服务项目包含但不仅限于有机/无机成分与结构分析,药物及聚合物定性/定量分析,材料结构及功能分析,多肽及生物大分子构象/动力学和稳定性分析,临床标志物的代谢组学分析,以及水质检测、食品检测、环境污染物检测等,积极为地方和国家的科研和经济建设提供助力。
The Instrumentation and Service Center for Molecular Sciences (ISCMS) is a shared-use core facility at Westlake University and has been devoted to developing novel characterization technology to promote the discovery and innovation of applied/basic sciences. With state-of-the-art equipment and developed analytical methodology, ISCMS explores the fundamental principles of chemical changes and energy flow at the atomic and molecular levels, serving forefront research fields of molecular synthesis, green catalysis, energy conversion, environmental science, chemical biology, biophysics and pharmaceutical science etc.
ISCMS provides 7*24 access and collaborative multidisciplinary research environment for the Westlake research community as well as the larger community of external researchers both from academia and industry through its five main laboratories:
(1) Magnetic Resonance Lab specializes in ultra-high resolution and in-situ analysis of molecular structures, interactions, and dynamics with novel designed and sophisticated NMR/EPR pulse sequences.
(2) Chromatography-Mass Spectrometry Lab focuses on the designable high-throughput experimentation of molecular synthesis while imparting expert knowledge in separation sciences to continuously extend the resolution and sensitivity.
(3) Spectroscopy Lab provides regional-controlled sub-micrometer resolution characterization, combined with microscopy and self-developed operando devices, to advance investigations into energy level structure, molecular geometry, chemical bond properties and reaction kinetics down to femtoseconds.
(4) Microstructure and Morphology Characterization Lab is dedicated to the development of high-resolution, in-situ, and micro-area XRD techniques, along with the construction of multi-physics coupled in-situ testing platforms (integrating light, electricity, force, heat, magnetism, etc).
(5) High-Throughput Precision Chemistry Lab integrates HTE and HTS system to enable automated molecular synthesis and functional screening, accelerating breakthroughs in catalysis, chemical biology, materials science, and drug development across scales from nanoliter operations to organoid-level analysis.
Advance techniques that address problems emerging from dynamic, cutting-edge researches include (I) high-field in situ liquid nuclear magnetic resonance, ultra-high resolution solid-state nuclear magnetic resonance, and liquid helium cryogenic pulsed electron paramagnetic resonance; (II) high-resolution and high-sensitivity liquid chromatography/mass spectrometry and gas chromatography/mass spectrometry, time-of-flight secondary ion mass spectrometry, full-element precise quantification, and combined optical spectroscopy and mass spectrometry; (III) femtosecond-to-second multi-time-scale time-resolved spectroscopy, super-resolution fluorescence/Raman/UV/IR spectroscopic imaging, operando X-ray absorption/emission spectroscopy, near-ambient pressure X-ray photoelectron spectroscopy, and liquid metal target X-ray single-crystal diffractometer and small-angle scattering; (IV) high-throughput chemical reaction screening/optimization system for catalytic chemistry and chemical biology.
The focus of staff scientists at ISCMS has been not only to serve a broad, diverse, international set of researchers, but also to develop specialized methodologies, protocols, instrumentation, and expertise to help simulate, characterize, and analyze novel molecules, materials, and systems going beyond conventional approaches.