1、负责核磁共振波谱仪的技术服务和日常管理工作；

2、负责培训各课题组成员相关仪器设备的基本知识和原理、样本制备、数据分析等；

3、积极协助各课题组的科学实验和基金申请；

4、完成部门领导交办的其他工作。

1. Responsible for the technical service and daily management of NMRspectrometer; 

2. Responsible for training researchers to master the basic principle of NMR spectrometer, sample preparation, data analysis, etc.;

3. Assist researchers in the scientific experiment and applying for research projects;

4. Complete other tasks assigned by department leaders.

发表文章 (Publications):

Xiaohuo Shi, Chaoni Xiao, Yulan Wang and Huiru Tang*, Gallic acid intake induces alterations to systems metabolism in rats,J Proteome Res,12(2), 991-1006, 2013.

Li Xu,Xiaohuo Shiand Kaifeng Hu*, Quantification of multiple compounds containing heterogeneous elements in the mixture by one-dimensional nuclear magnetic resonance spectroscopy of different nuclei using a single universal concentration reference,Magnetic Resonance in Chemistry,52, 779–782, 2014.

Qinli Wan,Xiaohuo Shi,Jiangxin Liu, Aijun Ding, Yuan-Zhu Pu, Zhigang Li, Guisheng Wu, and Huairong Luo*, Metabolomic signature associated with reproduction-regulated aging in Caenorhabditis elegans,Aging,9(2), 447-474,2017.

Pengfei Zheng,Xin Su,Chenhong Fei,Xiaohuo Shi,Hongyao YinandYujun Feng*, Deep insights into the hydrolysis of N,N -dialkylaminoethyl methacrylates in aqueous solution with 1 H NMR spectroscopy,Journal of Polymer Science Part B Polymer Physics,56(12), 914-923,(2018).

Houchao Xu, Kun Hu,Xiaohuo Shi, Jianwei Tang,Xiaonian Li,Handong Sun and Pematenzin Puno*,Synergistic use of NMR computation and quantitative interproton distance analysis in the structural determination of neokadcoccitane A, a rearranged triterpenoid featuring an aromatic ring D fromKadsura coccinea,ORGANIC CHEMISTRY FRONTIERS, 6, 1619–1626,2019.

Xing Li, Huan Luo, Tao Huang, Li Xu, Xiaohuo Shi and Kaifeng Hu*,Statistically correlating NMR spectra and LC-MS data to facilitate the identification of individual metabolites in metabolomics mixtures,Analytical and Bioanalytical Chemistry, 411,1301–1309,2019.

科研项目 (Research Projects)

中国科学院科研装备项目，28Y62P9211Q1，利用高场核磁检测微量天然产物新方法的开发，主持，2016/12-2019/6。

（Instrument Developing Project of the Chinese Academy of Sciences, No. 28Y62P9211Q1, Development of a new method for the detection of trace natural products by high field NMR spectrometer, Project Leader, 2016.12 -2019.06）

国家重点研发计划，2017YFC0906900，应用于临床样本检测的超灵敏、高覆盖代谢组定量分析技术研发，参加，2017/07-2019/12。

（National Key Research and Development Project, No. 2017YFC0906900, Development of ultra-sensitive and high-coverage metabolome quantitative analysis technology for clinical sample detection, Participant,   2017.07-2019.12）

国家自然科学基金面上项目，21573258，立体异构酶MarH和StnK3的结构及其催化机制的研究，参加，2016/01-2019/12。

（National Natural Science Foundation of China, No. 21573258, Study on the structure and catalytic mechanism of stereoisomerase MarH and StnK3, Participant, 2016.01-2019.12）

国家自然科学基金面上项目，21778059，HSP90 CTD天然产物抑制剂的发现和基于复合物结构的优化研究，参加，2018/01-2021/12。

（National Natural Science Foundation of China, No. 21778059,         Discovery and Optimization of HSP90 CTD natural product inhibitors, Participant , 2016.01-2019.12）

专利授权 (Granted Patents)

胡凯锋，徐莉，施孝活，联合使用不同核的一维核磁共振混合物定量方法,专利授权号：ZL 2014 1 0490487.6

（Kaifeng Hu，Li Xu， Xiaohuo Shi，Quantification of multiple compounds containing heterogeneous elements in the mixture by one-dimensional nuclear magnetic resonance spectroscopy of different nuclei, NO. ZL 2014 1 0490487.6）